During the Crimean War broke out in 1854 in Europe a violent epidemic cholera which soon transcends the boundaries of Alps and upsets the whole of the peninsula, reaching rates high mortality in the provinces of Messina and Palermo.
2.
Maritime quarantine legislation ( Act of August 1, 1888 ) strengthened the Act of 1878, adding new Federal quarantine stations along the East and West coasts; March 1891 legislation made medical inspection of immigrants part of MHS's duties; and interstate quarantine legislation ( Act of March 27, 1890 ) gave MHS authority to establish quarantines against epidemic cholera, yellow fever, smallpox, and plague.
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